Endocrine Abstracts

ObjectiveTo investigate whether salivary cortisol could provide an alternative to serum cortisol for hypocortisolaemic patients undergoing hydrocortisone day curves.MethodCorrelational study of 58 patients receiving corticosteroid replacement therapy for primary (9) or secondary (49) hypocortisolaemia. Paired samples of saliva and serum were taken at pre-determined time points throughout a 7½ hour hydroc...

Summary: Physiological replacement of glucocorticoids in hypocortisolemic patients remains a challenge. We assessed the use of salivary cortisol and total serum cortisol profile with CBG measurement in monitoring glucocorticoid replacement in hypoadrenal patients in routine clinical practice.Methods: Serum and salivary cortisol concentrations were measured in 60 hypoadrenal patients previously documented to have cortisol deficiency on provocative testing...

IntroductionSevere physical, and psychiatric illnesses are characterised by high cortisol levels and disturbance in circadian rhythm. A distinct awakening cortisol response and a marked diurnal decline is reported to be associated with better physical and psychological health, deviations from this pattern are negative for health. It is however not known if ITU patients have any specific cortisol pattern associated with their altered sleep awakeness cycle...